Imagine An Answer has partnered with a Johns Hopkins University lab operated by Dr. Eric Rabbe, MD, P.h.D. to focus on finding a cure for pediatric low grade gliomas (LGG’s).  This research is focusing on:  

  • Identification of a gene called mTOR that is activated in the brain tumors of patients whose LGG has relapsed. This is key because identification of this gene enables Dr. Raabe and his team to zero in on a specific gene that signals the reappearance of LGG
  • Testing of a drug called sapanisertib, which is a so-called mTOR “inhibitor” that prevents the activation of the mTOR gene
  • Determination of whether sapanisertib can work together with chemotherapy to enhance the killing of LGG cells
  • Testing of another drug called trametinib, which is currently in clinical trials for LGG, to assess whether this drug can work with chemotherapy or sapanisertib to kill LGG cells

Both of these experiments, if successful, will provide the needed rationale to start clinical trials of sapanisertib and trametinib plus chemotherapy in patients whose LGG has returned.

Dr. Raabe and his team are taking both a long-term approach in developing new systems to find drugs for LGG and also immediate steps to fight this deadly disease today.